Researcher | Former Marie Skłodowska-Curie Fellow
Areas of Research
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Crystallization of small molecules: Classical and nonclassical crystallizations, mesocrystals, hierarchical structure, reversed crystals growth, nucleation, and in situ studies.
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Lanthanide doped nanophosphors: Crystal site engineering approach, dopant influences, structure-property study, UC nanomaterials.
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Organic Materials: Nonlinear optical crystals, Terahertz generation, cocrystals, salt, polymorphism, crystal structure solution.
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Density Functional Theory: Gaussian 09 for molecular optimization, vibrational studies and solvent influences.
Latest Research
What Clients Say
Liquid-liquid phase separation (LLPS) or oiling out during crystallization of pharmaceutical solids is common and this dense phase before nucleation is not well understood in view of their role in alternative nucleation mechanism. Here we experimentally evidenced the core-shell structure formation via nonclassical crystallization (NCC) of ibuprofen (IBU) which commonly undergoes LLPS. We investigated the dense precursor phase using both solid and solution phase Raman and SAXS analytical tools and uncovered the molecular structural ordering and its role in nucleation. The role of different additives, solvent ratio, and pH in core-shell structure formed via reversed crystal growth were investigated and a possible mechanism for the transformation from dense phase to crystalline has been proposed. The nanoparticles are the building unit and their cross-sectional images were obtained via focused ion beam (FIB) cut. Due to intrinsic structural features, the core-shell structure of IBU enhanced the dissolution. The LLPS followed by core-shell structure, liquid phase Raman and SAXS results and dissolution enhancement unfold the new perspective of ibuprofen crystallization via NCC.
